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In a cervical cancer cell line (HeLa), the compound reduced cell proliferation in a concentration- and time-dependent way and lowered expression of phospho-Akt and SIRT1, two proteins tied to tumor progression, while a non-cancer reference cell line was less affected

EC 1.11.1.7) activity was determined following the method of Kar [24], 5 ml of mixture contained 300 M of phosphate buffer (pH 6.8), 50 M pyrogallol, 50 M H 2 O 2 and one ml of enzyme extract were prepared